In summary, we have developed an expedient route for the construction of benzothiophene and indole derivatives via propargylallene rearrangement and allyl migration. Benzothiophene manufacturer, benzothiophene suppliers. Synthesis and antimicrobial activities of benzothiophene derivatives article pdf available in journal of the chilean chemical society 571. The pyrrole ring in the indoles readily undergo subistitution reactions. Download your new pdf and save it to your computer. Structurally important biarylthioether, benzobthiophenes, and thieno3,2b thiophene scaffolds are provided in high yield. Benzothiophene carboxylate derivatives as novel allosteric. Files are available under licenses specified on their description page. Erfahre, wie du mit adobe acrobat dc eine ppt in eine pdf datei. Ramendra pratap, in the chemistry of heterocycles, 2019. It occurs naturally as a constituent of petroleumrelated deposits such as lignite tar. Synthesis of benzothiophene and indole derivatives through. Make ppt and pptx slideshows easy to view by converting them to pdf.
Kostenloser pptzupdfconverter online ppt zu pdf konvertieren. Novel benzofuranbenzothiopheneincorporated triphyrins2. After a short initiation period of about 5 minutes, hydrogen gas was seen to be evolved and. Oxidation of benzothiophene, dibenzothiophene, and methyl. Benzothiophene is an aromatic organic compound with a molecular formula c8h6s and an. Predominant antagonism of 5ht 2a receptors with a lesser degree antagonism of dopamine d 2 receptors has efficacy against negative symptoms esp. Synthesis of c2 substituted benzothiophenes via an. Follow these instructions to set the print quality of the pdf. The subsequently generated benzothiophenium salts undergo a previously unexplored 1,2. Synthesis and evaluation of a series of benzothiophene. An interrupted pummerer reaction between benzothiophene s. Mar 12, 2018 an interrupted pummerer reaction between benzothiophene s. Save powerpoint presentations as pdf files office support.
Kt462, which can grow on either benzothiophene bt or dibenzothiophene dbt as the sole source of sulfur, was newly isolated and characterized. Full paper results and discussion previously, we reported on synthetic methodologies for the preparation of thieno2,3dpyrimidinebased bisphosphonate10 and monosphosphonate thpmps11 libraries of com pounds with the ability to inhibit isoprenoid biosynthesis. Its various derivatives are useful as pesticides, fungicides, and herbicides. Synthesis and antimicrobial activity of benzothiophene. The desulfurized product of dbt produced by this strain, as well as. Very general involves the dehydration of 1,4dicarbonyl compounds.
Moreover, bt2related benzothiophene hydroxamic acids are botulinum nerotoxin serotype a protease inhibitors. Thiophene soxides and thiophene epoxides are highly reactive electrophilic thiophene metabolites whose formation is cytochrome p450dependent. The reaction proceeded under mild conditions to produce useful benzothiophene and indole derivatives. This free online converter allows to convert various file formats doc, docx, xls, ppt, jpg, png. After a short initiation period of about 5 minutes, hydrogen gas was seen to be evolved and the reaction temperature began to rise rapidly. Medicinal chemistry heterocyclic compounds free download as powerpoint presentation.
Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Pdf converter is a online webbased document to pdf converter software. Anaerobic biodesulfurization of thiophenes wur edepot. Mar 31, 2017 new benzothiophene derivatives as dual cox12 and 5lox inhibitors. The presence of high amounts of sulfur in soils adjacent to the study area was reported by fernandez et al. All structured data from the file and property namespaces is available under the creative commons cc0 license. Instantly convert text documents, presentations, spreadsheets and images to pdf format with this free online pdf converter. Under print quality paper pdf, set the desired quality to an option of your choice. Aug 30, 2014 the present paper investigates the oxidation of benzothiophene bt, dibenzothiophene dbt, and 4methyldibenzothiophene 4mdbt by ferratevi.
New benzothiophene derivatives as dual cox12 and 5lox. The pyrite rejection is dependent to the particle size distribution of pyrite. The photooxidation of benzothiophene followed the first order reaction law, with the rate constants ranging from 1. Different substitution patterns in these heterocycles provide new opportunities for. Soluble in ethanol, soluble in ether, acetone and general organic solvents, insoluble in water. Gib deine fertiggestellte powerpointprasentation in einem flexibleren dateiformat aus. Thiophene is ppt on a modest synthesis of around alkylthiols to provide thiophene trifluoroborates in high pdf with.
Dibenzothiophene is a mancude organic heterotricyclic parent that consists of a thiophene ring flanked by two benzene rings orthofused across the 2,3 and 4,5positions. To construct more desirable adsorption affinity between the current metalorganic frameworks and benzothiophene bt, a novel desulfurizer vcubtc, where btc represents 1,3,5benzenetricarboxylic acid was prepared by reducing cuii to cui with viii on cubtc using a. Thianaphthene 1 also known as benzothiophene was first obtained by difficult. The word indoles derived from the word india blue dye. Introduction to the compound bazedoxifene acetate way140424. Highly efficient benzothiophene capture with a metal. Kinetic investigation into the photochemical oxidation of benzothiophene in seawater showed that photooxidation rates of benzothiophene were influenced by the medium, ph, heavy metal ion, dissolved oxygen, and light intensity. A ftir study of the adsorption of indole, carbazole. Penthala nr1, sonar vn, horn j, leggas m, yadlapalli js, crooks pa. Synthesis and antimicrobial activities of benzothiophene.
Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. Benzothiophenes heterocyclic building blocks sigmaaldrich. It is a member of dibenzothiophenes and a mancude organic heterotricyclic parent. Specialized thiophenes can be synthesized similarly using lawessons reagent such as a bright counter and display endosymbiotic hypothesis quizlet medical terminology on a synthesis than pdf. Ppt thiophene powerpoint presentation free to view. Organic chemistry program of study committee william s. A free powerpoint ppt presentation displayed as a flash slide show on id. Predicted data is generated using the us environmental protection agencys episuite. Biodesulfurization of benzothiophene and dibenzothiophene. In the powerpoint preferences dialog box, click general. Mar 20, 2017 the synthesis of these important molecules can be achieved by construction of one or both rings, or via direct functionalization of the benzothiophene core 9,10,11.
In the present research manuscript, we described a series of new compounds containing coumarins, pyrimidines and pyrazole substituted benzothiophene derivatives 3af, 4, 5, and 7 have been synthesized from 2,4diflurobenzonitrile and methyl thioglycolate as starting material. Photochemical oxidation of benzothiophene in seawater. In a 3month study, arzoxifene prevented estrogendeficiencyinduced bone loss in ovariectomized ovx rats 16. General read this before lecture 3 thiophenes and pyrroles are also extremely important compounds vital for the chemistry of. Learning outcomes by the end of the lecture, students will be able to 1. Sales training role of atp atp adenosine tri phosphate.
A mechanistic study of photochemical deoxygenation by mrinmoy nag a dissertation submitted to the graduate faculty in partial fulfillment of the requirements for the degree of doctor of philosophy major. It is considered to be a structural alert, as its metabolism can lead to the formation of reactive metabolites. Benzothiophene is regarded as a privileged class of structure showing a wide spectrum of biological activities. Ppt benzothiophene powerpoint presentation free to. Visible light photocatalytic synthesis of benzothiophenes organic.
Biodesulfurization of benzothiophene and dibenzothiophene by. The birch reductions of benzothiophene and dibenzothiophene have been studied for a number of years. Furan, thiophene and pyrrole are aromatic by virtue of their planarity and the uninterrupted. Ppt benzothiophene powerpoint presentation free to view. The effects of reaction conditions such as the reaction medium ph, solvent type, and adsorbent on the reactivity of ferratevi with the thiophenecontaining compounds were investigated. Ppt thiophene powerpoint presentation free to view id. Benzothiophene article about benzothiophene by the free. For the desulfurization of benzothiophene bt two different parallel reactions with h2 are. High resolution image download ms powerpoint slide. A benzothiophene in which the benzene ring is fused to the thiophene ring across positions 3 and 4. Antiinflammatory and analgesic benzothiophene and benzafuran. Very small and highly disseminated pyrite particles are nearly impoosible to separate from coal. Gc and gcms analyses revealed that strain kt462 has the same bt desulfurization pathway as that reported for paenibacillus sp.
The present paper investigates the oxidation of benzothiophene bt, dibenzothiophene dbt, and 4methyldibenzothiophene 4mdbt by ferratevi. Figure 2 is a new benzothiophene analog that is structurally related to raloxifene. Photocatalytic degradation of benzothiophene and dibenzothiophene using supported gold nanoparticle article pdf available in journal of saudi chemical society 2 november 2016 with 8 reads. Oct 22, 1985 a solution of the benzothiophene ester 0. Synthesis of 1benzothieno3,2b1benzothiophene derivatives via. In a longterm study, arzoxifene at oral doses of 0. New benzothiophene derivatives as dual cox12 and 5lox inhibitors. Pdf photocatalytic degradation of benzothiophene and. Benzothiophenes, an important class of heterocycles, are privileged structures, used as starting materials for the synthesis of bioactive structures, and are present in pharmaceuticals. No file size restrictions, no ad watermarks just a free online tool for creating pdfs from your ppt slides.
It is used in organic as well as pharmaceutical industry as a component in the synthesis of raloxifene, a breast cancer therapeutic, or hydrodesulfurization reactions. Thiophene is a fivemembered, sulfurcontaining heteroaromatic ring commonly used as a building block in drugs. Bioactivation potential of thiophenecontaining drugs. Wandeln sie ppt oder pptxdateien schnell in ein pdfdokument um. Benzothiophene is an aromatic organic compound with a molecular formula c 8 h 6 s and an odor similar to naphthalene mothballs. Mochten sie ihre ppt zu einer pdfdatei konvertieren. The developed synthetic method couples aryl or heteroaryl bromides with thiophenes bearing electrondonating or electronwithdrawing groups and other heterocyclic moieties such as benzothiophene, benzofuran, and pyrrole with very good yields. Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. A palladiumcatalyzed ch arylation of electronenriched heteroarenes with aryl bromides and aryl chlorides. Snar occurs readily on benzothiophenes, but they have some strange reactions with. Schematic presentation of the configuration used in the validation.
Tse424 is an oral, nonsteroidal, indolebased serm being developed for the prevention and treatment of osteoporosis. Download as ppt, pdf, txt or read online from scribd. Pages in category benzothiophenes the following 16 pages are in this category, out of 16 total. The synthesis of these important molecules can be achieved by construction of one or both rings, or via direct functionalization of the benzothiophene core 9,10,11. It was designed to improve the bioavailability of raloxifene and provide sustained antiestrogenic blockade in the treatment of. The lonepair electrons of the nitrogen atom cause amines to react as bases, sharing the lone pair with a proton, and as nucleophiles, sharing the lone pair with an atom other than a proton.
When the conversion is done, your ppt, pptx, and pdf files will be automatically deleted. Powerpoint in pdf umwandeln kostenloses online tool. Benzobthiophene is used in the preparation of 2thianapthenylphenyllithium, via metalation by nbutyllithium. Jul 01, 20 synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents.
154 91 444 1112 1149 1230 123 35 56 1040 824 426 1055 1567 61 730 172 1417 1249 286 548 510 1394 287 887 106 1136 1286 8 979 1122 61 859 902 794 1179 1389 1142 924 1001 1413 336 1013